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In particular, we show that GTP-binding triggers interhelical interactions and subsequent anticlockwise motion of nucleotide-binding domain (NBD) involving the Rossmann folds that eventually close the catalytic cleft

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Chen C, Nirunsuksiri W (1999) Decreased expression of glutathione S-transferase M1 in HPV16-transfected human cervical keratinocytes in culture

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Therefore, clinicians frequently use it to calm sensitive skin types